… Regulation of longevity by bile acids was first observed in Little mice, … The increased levels
of bile acids in these long-lived mice … Increased total bile acid levels have also been observed …

… /− mice (95), it is still not fully established how FXR signaling keeps hepatic fat deposits in
check. While a comparative study in liver- and intestine-specific Fxr −/− mice demonstrate that …

… GH signaling during development on longevity, we re-examine this issue in both sexes of
normal and longlived mutant mice. … Bile acids induce the expression of the human peroxisome …

… on long-lived mutant mice, including the Ames dwarf mice and calorically restricted mice, as
… We discuss these in the light of data on long-lived Ames dwarf mice (Brown-Borg et al. 2014…

… released into an ecosystem by animals may act as interspecies chemical signals that … other
bile acid. Our findings imply that the prolonged longevity of each of the three long-lived yeast …

… Based on our prior studies with the bile acid–activated nuclear … Interestingly, in long-lived
Ames dwarf mice, renal FXR and … mice, we do not believe that the signals are specific for TGR5. …

… of longevity, which is induced in the long-lived transgenic C. … of bile acids in longevity
regulation was first revealed through the transcriptome and biochemical analysis of the Little mice, …

… lifespan are known, but general principles of lifespan exten… ) analyses of mice subjected to
8 longevity interventions. We … (GHRKO, Little mice, and Snell and Ames dwarf mice). The latter …

… In mice, very hydrophilic bile acid species may actually promote transintestinal cholesterol
… at age 60 was found to be associated with lower odds of longevity, defined as attaining 80 …

… exists in long-lived mice, we examined if oxylipins were differentially regulated in Ames dwarf
mice. … To determine which of these signaling lipids could be secreted from the BAT of Ames …